MacKinnon center's Colorado's top line with wingers Rantanen and Gabriel Landeskog, and the trio combined for 10 points (four goals, six assists) in the outing.
"Your first line has got to be driving the boat, and we are making sure that we are leading," said Landeskog. "That's what we kind of wanted to do tonight, just come out and lead the charge right off the get go and we did that."
The three forwards have been together almost exclusively since Oct. 28 and have combined for 130 points (52 goals, 78 assists) in 32 home outings this season.
"When you play that long time together, since end of October or something, the chemistry comes kind of automatically," said Rantanen. "Of course, we like to talk before the games too and in the middle of the game [about] what we want to do on the ice. Just two great players helping me, so it's a lot of fun to play with them."
MacKinnon finished the game with a plus-5 rating, the first Avalanche player to do so since Rob Blake was also a plus-5 on March 19, 2006 at the San Jose Sharks.
The 22-year-old has 11 points (six goals, five assists) in his last four outings.
"We have been doing our thing at home for a while now," MacKinnon said of his line. "A little break from each other when I got hurt I guess, and coming back with one another we kind of picked up where we left off and tonight was a fun one."
MacKinnon had an upper-body injury for eight games at the beginning of February and did not miss a beat upon his return.
"You never know, injuries are always tough. But I think a guy that had his confidence so high right before he went out and obviously coming back and he just sort of picks up right where he left off," said Landeskog. "That's impressive. It's not easy to do to, sit out and just come back like that but he's done a good job."
Since he has returned from injury, MacKinnon has registered 15 points (seven goals, eight assists) in seven games, including a four-game goal streak.