Stamkos and Hedman led the way for the Bolts offensively with each collecting three points. J.T. Miller, Point and McDonagh also registered multiple points on the night.
Making his first start since March 9, Louis Domingue stopped 25 shots to earn his 21st win of the season.
Also in the victory, Jon Cooper earned his 300th career win behind the Lightning bench.
The Bolts will be off tomorrow before facing the Blues in St. Louis on Saturday night in the finale of this three-game road trip.
Scoring Summary
1st Period
TBL | 3:20 Steven Stamkos (38) - Victor Hedman, Brayden Point - PPG
CAR | 9:51 Justin Williams (23) - Nino Niederreiter, Sebastian Aho
CAR | 11:32 Dougie Hamilton (14) - Andrei Svechnikov, Jordan Staal
TBL | 19:34 Tyler Johnson (27) - Ryan McDonagh, Nikita Kucherov
2nd Period
CAR | 6:34 Jordan Staal (8) - Teuvo Teravainen, Brett Pesce
3rd Period
TBL | 3:35 Anthony Cirelli (17) - Steven Stamkos, Victor Hedman
TBL | 10:09 Ryan Callahan (7) - Victor Hedman, J.T. Miller
TBL | 16:36 Brayden Point (39) - Steven Stamkos, J.T. Miller
TBL 18:55 Ryan McDonagh (9) - Unassisted - EN