MacKinnon is one game away from tying Joe Sakic (23) for the longest home point streak at any point in a season in Avalanche/Quebec Nordiques history.
Valeri Nichushkin scored the only goal of the shootout.
Mikko Rantanen, Logan O'Connor, and Sam Malinski each scored for the Avalanche (26-12-3), who have won seven of their past nine games (7-1-1). Alexandar Georgiev made 24 saves.
Brad Marchand scored twice, and John Beecher scored for the Bruins (24-8-7), who had won five of their past six (5-1-0). Jeremy Swayman made 33 saves.
Marchand gave Boston a 1-0 lead at 11:21 of the first period on the power play, scoring on a wrist shot from the top of the left circle that beat Georgiev glove side.
Rantanen tied it 1-1 at 16:13 with a power-play goal when he choked down on his stick, dropped to one knee, and redirected MacKinnon’s pass over the glove of Swayman.
O’Connor gave Colorado a 2-1 lead at 2:23 of the second period. He grabbed the puck after Kevin Shattenkirk and Pavel Zacha collided in their own zone, turned and stick-handled down on Swayman, beating him glove side on the breakaway.
Beecher tied 2-2 at 10:05 after scoring off the rebound of Danton Heinen’s wraparound shot.
Malinski put the Avalanche ahead 3-2 at 17:56 of with a wrist shot from the blue line.
Marchand tied it 3-3 at 5:46 of the third period when he crashed the far side of the net and redirected Charlie Coyle’s cross-zone pass.
