Alex Killorn and Anthony Cirelli scored the Lightning's goals.
Andrei Vasilevskiy gets saddled with the loss after making 19 saves on 22 shots.
Tampa Bay now hits the road for a pair of games against the Devils in Newark on Tuesday and Thursday.
Scoring Summary
1st Period
TBL 1, WPG 0
1:19 Alex Killorn (20) - Anthony Cirelli, Brandon Hagel
A backhand feed from Anthony Cirelli found Alex Killorn open in front of the net and his shot just barely squeaked through Connor Hellebuyck. The puck had just enough on it to trickle over the goal line before Nate Schmidt could clear it away.
TBL 1, WPG 1
10:15 Nate Schmidt (7) - Logan Stanley
Schmidt's shot from the point took an inadvertent deflection of Michael Eyssimont in the slot that caused the puck to change direction and slip through Andrei Vasilevskiy's five-hole.
2nd Period
WPG 2, TBL 1
1:01 Nino Niederreiter (21) - Mark Scheifele, Blake Wheeler - PPG
Tampa Bay fell behind one minute into the second period on a Nino Niederreiter power play goal. Niederreiter stepped to the front of the net and jammed a shot through Vasilevskiy to give the Jets the lead.
WPG 3, TBL 1
9:04 Morgan Barron (7) - Brenden Dillon, Mason Appleton
Brenden Dillon crashed the net and made contact with Vasilevskiy, causing him to go down at the far post. With Vasilevskiy out of position, Morgan Barron pounced on the rebound and fired it home. Tampa Bay challenged for goaltender interference, but the call on the ice was confirmed following the review.
WPG 3, TBL 2
10:01 Anthony Cirelli (10) - Brandon Hagel - SHG
After the unsuccessful challenge, what could have been a huge momentum swing toward Winnipeg on the ensuing delay of game penalty went the opposite direction. Anthony Cirelli chased down a feed from Brandon Hagel at the blue line and beat Hellebuyck on the breakaway for a shorthanded goal.
3rd Period
No Scoring
