Knuble, who made his NHL debut on Monday in a 3-2 win against the Colorado Avalanche, is the son of former NHL forward Mike Knuble, who played 338 of his 1,068 career games with Philadelphia.
Trevor Zegras scored, and Oliver Bonk had two assists for the Flyers (3-6-3). Dan Vladar made 27 saves.
Jason Zucker scored, and Ukko-Pekka Luukkonen made 23 saves for the Sabres (4-4-2), who had a four-game point streak end (2-0-2).
Knuble gave Philadelphia a 1-0 lead at 14:49 of the first period. He cleaned up the rebound of Bonk’s point shot with a backhand from in front, deking it around the crease and past Luukkonen’s right skate.
Zegras pushed it to 2-0 at 19:17 on the power play. He batted in Matvei Michkov's blast from the right dot while it was still midair over the stick of Luukkonen.
Zucker, making his season debut after offseason sports hernia surgery, scored on the power play to cut it to 2-1 at 19:25 of the second period. Jack Quinn spotted him at the crease to Vladar’s left and put a centering feed toward the net that redirected off the shaft of Zucker’s stick.
Knuble’s second of the game put the Flyers ahead 3-1 at 3:03 of the third period. Buffalo defenseman Louis Crevier lost his stick in a puck battle, leaving him defenseless against the Bonk and Knuble tandem in the offensive zone. Knuble took a short pass from Bonk to the net and tucked it behind Luukkonen’s left leg.
