Buffalo, coming off a 5-2 victory over the Toronto Maple Leafs on Friday night, couldn't match the intensity of the Senators, getting out shot 37-25 in the contest.
In three games this season, Ottawa has outscored Buffalo 21-5.
"I look at it this way," said Sabres' goaltender Martin Biron of the scoring differential. "We made them look good on most occasions, but these guys in (the Sabres lockerroom) can play with those guys. We just need to do it for 60 minutes."
Biron took the loss for Buffalo, allowing four of Ottawa's six goals in the second period.
"As soon as they saw some blood, they really seemed to come out hungry," said Biron. "We gave them opportunities in the beginning of the second period. We were neck-and-neck with them in the first and third periods; they just saw blood in the second.
"We know what we have to do and this league is just a matter of winning one period sometimes. Tonight was proof of that."
spoiled Ottawa goaltender Ray Emery's shutout bid, scoring Buffalo's only goal of game and his first of the season at 14:21 in the third period. Emery finished the game saving 24 of 25 shots faced.
Teppo Numminen was credited with the second assist on Roy's goal and leads the team in assists with 12.
With just 0.2 seconds remaining on the clock, Ottawa scores off a Chris Neil shot from the right point to head into the first intermission with a one-goal lead.
The goal was reviewed and upheld, despite the fact the goal lamp never went red.
Daniel Alfredsson extends Ottawa's lead to two goals at 0:59 of the second, scoring on an odd-man rush following a Buffalo turnover in the neutral zone. Alfredsson's wrist shot hit the post but deflected off Martin Biron's back into the net.
Dany Heatley scored his first goal of the game just 16 seconds later to put Ottawa up 3-0 with a precision shot into the top right corner of the net from the left wing.
A goal by Mike Fisher on the power-play at 5:15 and a shorthanded goal by Heatley at 16:55 put Buffalo down 5-0 heading into the second intermission.
Jason Spezza finished the scoring for the Senators with a goal at 5:30 of the third.
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0-1 (19:59): With just 0.2 seconds remaining on the clock, Ottawa scores off a Chris Neil redirect on Bryan Smolinski shot from the right point to head into the first intermission with a one-goal lead. Smolinski and Brian Pothier record the assists.Period 2
0-2 (0:59): Daniel Alfredsson scores on an odd-man rush following a Buffalo turnover in the neutral zone. Alfredsson's shot hit the post but deflected off Martin Biron's back into the net. Wade Redden is credited with the only assist.
0-3 (1:15): Dany Heatley scores just 16 seconds later to extend Ottawa's lead to three. Heatley fired a precision shot into the top right corner of the net from the left wing for his 14th goal of the season. Daniel Alfredsson records his second point of the game with the only assist.
0-4 (5:15): Mike Fisher slams home a loose puck after Martin Biron couldn't control the rebound off Zdeno Chara's point shot. Chara and Bryan Smolinski get the helpers. The marker is the first power-play goal of the game.
0-5 (16:55): Dany Heatley scores a shorthanded goal after receiving a nice pass in front of the net from Zdeno Chara on an odd-man rush. Ottawa's six shorthanded goals currently leads the NHL. Mike Fisher gets the second assist.Period 3
0-6 (5:30): Brian Pothier gets his first of the game with a goal that extends Ottawa's lead to six. Jason Spezza and Daniel Alfredsson record the assists.
1-6 (14:21): Derek Roy
scores his first goal of the season after receiving a nice pass by Dmitri Kalinin from behind the net. Kalinin and Teppo Numminen record the assists. Numminen's 12 assists lead the Sabres.
Quotes courtesy of WGR 550-AM, the official radio partner of the Buffalo Sabres.