Upshall was selected by the Nashville Predators with the No. 6 pick in the 2002 NHL Draft, making it an even more eventful year. He already had been named the top rookie in the Western Hockey League and Canadian Hockey League for 2011-12, skated in the CHL Top Prospects Game and won a silver medal with Canada at the 2012 World Junior Championship.
Upshall would continue his winning ways as a professional. In 2003-04 he won the Calder Cup with Milwaukee of the American Hockey League, and in 2005-06 he helped Milwaukee reach the Calder Cup Finals.