1:29 into the game, Colorado struck for the game's first goal. Ian Laperriere picked up a rebound from Tyler Arnason and slipped it past Dwayne Roloson to give the Avs an early 1-0 lead.
Two minutes into the game, shots on goal were 6-0 Colorado.
The Avalanche doubled their lead three minutes later as Joe Sakic took a feed from Andrew Brunette behind the Edmonton net and one-timed a shot from the slot through the five-hole of Roloson.
By the eight-minute mark, shots were 12-1 for the Avalanche.
Matt Greene came close to scoring the Oilers' first of the game after taking a cross-ice pass from Patrick Thoresen. Greene was all alone in front but couldn't get a handle on his deke attempt to get the puck around Budaj.
Shots after one period were 17-6 for the Avalanche.
The second period started much the same as the first with Colorado getting an early goal. Tyler Arnason fed a no-look pass off the end boards to Laperriere in front and he made no mistake, wristing it glove side behind Roloson.
The game's first penalty didn't come until nearly midway through the second when Pisani was sent off for slashing. On the ensuing power play. Roloson made a huge save off Sakic. The Colorado captain took a feed from Paul Stastny but the Oilers goaltender got across to kick the puck out.
A penalty to Robert Nilsson with seven minutes to go in the middle frame led to Colorado's fourth of the game. John-Michael Liles pounced on the puck in the slot and wristed it over the shoulder of Roloson.
The goal ended Roloson's night as he was replaced by Jussi Markkanen at that time.
Markkanen made an impact almost immediately upon his placement into the Oilers net with a trio of saves off Wojtek Wolski from point-blank range. The Avalanche rookie couldn't get the puck behind Markkanen on three attempts.
However, Brett Clark moved Colorado in front 5-0 with 4:01 to go in the period. Colorado skated in on a three-on-one that concluded with Brunette feeding Clark in the slot. Markkanen couldn't get across in time to stop the tap-in goal.
Edmonton finally received its first power play of the night with five seconds to go in the second - Kurt Sauer two minutes for hooking.
Shots after two periods were 28-13 for Colorado.
With Zack Stortini in the box, Patrick Thoresen scored 5:33 into the third period to spoil Budaj's shutout bid. Pisani took the initial shot on goal and Budaj made the save but Thoresen was stationed in front where he chopped the rebound in.
Seven minutes into the third, Stortini dropped the gloves with Laperriere. The two wrestled for about a minute before Stortini took the Avs forward down to the ice. Stortini received two for roughing while Laperriere got two for roughing and two for holding.
Edmonton continued to carry the play in the third period, outshooting Colorado 8-2 through the first 15 minutes of the final frame.