DeAngelo was selected by the Tampa Bay Lightning in the first round (No. 19) in the 2014 NHL Draft after he led all Ontario Hockey League defensemen with 71 points (15 goals, 56 assists) for Sarnia in 2013-14. DeAngelo signed a three-year, entry-level contract on Dec. 2, 2014.

On Jan. 8, 2015, Sarnia traded him to Sault Ste. Marie, where he finished the season with 89 points (25 goals, 64 assists), again leading all defensemen in the OHL. He won the award for top defenseman in the OHL (Max Kaminsky Trophy) and the Canadian Hockey League (Superstore Defenseman of the Year).

DeAngelo spent his first pro season with Syracuse of the American Hockey League in 2015-16, finishing with 43 points (six goals, 37 assists) in 69 games.

At the 2016 NHL Draft, he was acquired by the Arizona Coyotes in a trade with the Lightning. He began the season with Tucson of the AHL but was recalled by the Coyotes on Nov. 7, 2016 and made his NHL debut the following night, scoring his first NHL goal in a 4-2 win against the Colorado Avalanche.

DeAngelo had 14 points (five goals, nine assists) in 39 games for Arizona, but was acquired by the New York Rangers along with the No. 7 pick in the 2017 NHL Draft for forward Derek Stepan and goalie Antti Raanta on June 23, 2017. DeAngelo split the 2017-18 season between the Rangers and Hartford of the AHL. He had eight points, all assists, in 32 games with New York before missing the final 12 games with an ankle injury.

DeAngelo had his first NHL hat trick and scored five points in a 6-3 win against the New Jersey Devils on Jan. 9, 2020.

DeAngelo was waived by the Rangers on Feb. 1, 2021, and after clearing waivers was assigned to the taxi squad. The Rangers bought out the final year of his contract July 24, 2021, and he signed a one-year contract with the Carolina Hurricanes four days later.

DeAngelo had a career high 41 assists with the Hurricanes in the 2021-2022 season and in 14 playoff games had 10 points (one goal, nine assists).

On July 8, 2022, DeAngelo was traded to the Philadelphia Flyers and signed a two-year, $5 million contract three days later.

NOTES & TRANSACTIONS

• OHL First All-Star Team (2015)
• Traded to Arizona by Tampa Bay for Arizona's 2nd round pick (Libor Hajek) in 2016 NHL Draft, June 25, 2016.
• Traded to NY Rangers by Arizona with Arizona's 1st round pick (Lias Andersson) in 2017 NHL Draft for Derek Stepan and Antti Raanta, June 23, 2017.
• Signed as a free agent by Carolina, July 28, 2021.
• Traded to Philadelphia by Carolina with a 7th-round pick in the 2022 NHL Draft for a 4th-round pick in 2022, 3rd-round pick in 2023 and 2nd-round pick in 2024, July 8, 2022.