Campbell scored from the inside edge of the left circle as the trailer on a 3-on-2 rush. It was his second goal of the season.
The Red Wings' Gustav Nyquist hit the goal post with 2:28 left in the third period.
Smith tied the game 1-1 with 5:22 left in the third when defenseman Aaron Ekblad's shot deflected in off of Smith. It was Smith's sixth goal.
Larkin gave Detroit a 1-0 lead at 7:02 of the second period. He intercepted Aleksander Barkov's pass up the middle, about 10 feet inside the Florida blue line, skated in and beat Luongo to the stick side. It was Larkin's 10th goal, which leads NHL rookies. He has six goals and an assist in his last seven games.
Mrazek preserved Detroit's lead just over four minutes into the third when he stopped Smith from the left circle and Brandon Pirri on the rebound. Mrazek also backstopped 1:27 two-man disadvantage in the middle of the second period.
Smith put a puck in the Red Wings net 28 seconds into the game but the play was ruled no goal because Panthers forward Jonathan Huberdeau interfered with Mrazek. Panthers coach Gerard Gallant challenged the no-goal call but the play was upheld.
|Power Play %||20.5%||15.8%|
|% on Road||8.6%||21.2%|
|% at Home||29.2%||11.6%|
|Mike Green Holding against Reilly Smith|
|Jonathan Huberdeau Interference against Mike Green|
|Mike Green Embellishment against Jonathan Huberdeau|
|Aleksander Barkov Holding against Henrik Zetterberg|
|Tomas Jurco Tripping against Brian Campbell|
|Mike Green Hooking against Jonathan Huberdeau|
|Darren Helm Tripping against Vincent Trocheck|
|Brian Campbell Tripping against Tomas Tatar|
|Jussi Jokinen Unsportsmanlike conduct against Tomas Tatar|
|Tomas Tatar Unsportsmanlike conduct against Jussi Jokinen|
|Justin Abdelkader Roughing against Erik Gudbranson|
|Erik Gudbranson Roughing against Justin Abdelkader|
|Darren Helm Hi-sticking against Reilly Smith|
|Logan Shaw Tripping against Pavel Datsyuk|
|Nick Bjugstad Hooking against Justin Abdelkader|