The defending Stanley Cup champions announced the deal on their Twitter account Monday, saying the trade is contingent on Regehr passing a medical exam.
In exchange, the Sabres acquired the Kings second-round picks in 2014 and 2015.
The 13-year NHL veteran will be an unrestricted free agent this summer, and waived his no-trade clause to approve the deal.
Regehr spent the past two seasons with Buffalo after 11 seasons with Calgary, where he played for Kings coach Darryl Sutter.
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