PHILADELPHIA -- The Philadelphia Flyers are set to begin their 2013-14 season against the Toronto Maple Leafs at Wells Fargo Center on Wednesday night, and there appear to be some changes from what was seen during the preseason.

Among the changes based on pre-game warmups are a new-look top line that features Brayden Schenn replacing Jakub Voracek at right wing alongside center Claude Giroux and left wing Scott Hartnell.

PHILADELPHIA -- Toronto Maple Leafs coach Randy Carlyle did not meet with reporters before Wednesday’s game against the Philadelphia Flyers at Wells Fargo Center, but it's expected that the only significant lineup change for them will be in goal. Jonathan Bernier is expected to get the start after serving as the backup in Tuesday’s 4-3 win against the Montreal Canadiens.

"I think both those guys in the preseason played really strong," Maple Leafs forward James van Riemsdyk said. "The one [preseason] game in Detroit we hung him out to dry a little bit. He's really solid. You notice it in practice, even trying to score on him then, he doesn't give you much to shoot at and he really competes in there."

DENVER -- Patrick Roy and Teemu Selanne will mark individual milestones Wednesday night at the Pepsi Center when the Colorado Avalanche and Anaheim Ducks begin regular-season play.

It will be Roy's first NHL game as a head coach when he goes behind the Avalanche bench. For Selanne, who has told the Ducks he plans to retire after the season, it will be his 22nd and final opening night.

"Yes, I'm nervous," Roy said following the morning skate. "There's nothing wrong for me to be nervous. I'm a proud person and I want to do well. I care, and when you care you have to be a bit nervous. I'm curious also to see the difference between preseason and how the (opposing) coaches are going to deal during the games, the adjustments I'm going to have to make. I'm convinced I'm going to learn a lot this year.

Dustin Penner and the Anaheim Ducks were reunited this past summer, but Penner will not be in the lineup when the team opens its 2013-13 season Wednesday night against the Colorado Avalanche in Denver.

Ducks coach Bruce Boudreau confirmed following Wednesday's morning skate that Penner is a healthy scratch. Penner was skating with coaches and extra players following practice, a good indicator that he's out of the lineup. It was last week when Boudreau called Penner's camp "mediocre," but the coach cited a strong camp from Patrick Maroon, expected to play left wing alongside Ryan Getzlaf and Corey Perry, as part of his reasoning behind the decision.

Buffalo Sabres coach Ron Rolston revealed Tuesday that promising young winger Marcus Foligno will not be suiting up for the team's season opener Wednesday night in Detroit against the Red Wings (8 p.m. ET, NBCSN). He also added that the 22-year-old was "not for sure" to play in the team's back-to-back games this weekend, Friday night at home against the Ottawa Senators and in Pittsburgh against the Penguins on Saturday.

Foligno has not played since sustaining an upper-body strain in the team's 5-3 preseason loss to the Toronto Maple Leafs on Sept. 22. Prior to the injury, Foligno had enjoyed a strong preseason for the Sabres, collecting three goals and four points in three games. He has been skating both alone and with the team, but has been sporting a red non-contact jersey.

"He's been skating and we've been trying him every morning," Rolston said. "He's been going out in the morning and trying it, but it's just not where it needs to be to put him in that situation where if he gets bumped [it could] set him back further."

Twenty-six goals were scored on a wild first night of NHL action and three more home openers are on tap for Wednesday night. NHL Live, at 5 p.m. ET on NHL Network, will recap #NHLFaceOff and look forward to Wednesday Night Rivalry on NBCSN. We'll talk to Pierre McGuire who will be "Inside the Glass" as new Atlantic Division foes face off in the Detroit Red Wings and Buffalo Sabres.

Plus, it's Patrick Roy's coaching debut tonight in Denver as the Colorado Avalanche take on the Anaheim Ducks. We'll be joined by Paul Stastny, who is ready to begin his eighth season in Colorado and is in the last year of his current contract. On the Ducks' side, Andrew Cogliano will join us as he prepares for his seventh NHL campaign. Amazingly, he's never missed a game in his 458-game career with the Oilers and Ducks.

Remember to submit your #AskEJ questions through Twitter via @NHLNetwork or @EJHradek_NHL, and join the conversation on Twitter as we ask you to pick the game of the night.

E.J. Hradek Game Picks Wednesday October 2nd:

Toronto Maple Leafs at Philadelphia Flyers - Maple Leafs

Buffalo Sabres at Detroit Red Wings - Red Wings

Anaheim Ducks at Colorado Avalanche - Avalanche

E.J.'s Season Record: 2-1-0

It appears as though Buffalo Sabres coach Ron Rolston will give a pair of 2012 first-round picks a chance to star on the same line to open the 2013-14 season against the Detroit Red Wings in the Wednesday Night Rivalry game at Joe Louis Arena (8 p.m. ET, NBCSN).

Mikhail Grigorenko, selected No. 12 in the 2012 NHL Draft, and Zemgus Girgensons (No. 14, 2012) were skating on the team's third line during the morning skate at Joe Louis Arena.

"I got some confidence from last year, so I think this year is going to be a lot better," Grigorenko told The Buffalo News. "I just want to prove to the coaches that they need me and do what I can do best, which is create offense, work hard and just show him that I can be really helpful for this team."

PHILADELPHIA -- For the first time in a long time, Philadelphia Flyers defenseman Andrej Meszaros is able to say he feels healthy.

Injures to his back and shoulder, as well as a torn Achilles tendon, has limited him 12 games since March 1, 2012. He played 11 games last season.

"I'm really excited," he told NHL.com after taking part in the team's optional skate Wednesday. "I can't wait to play again. It's been a while. Preseason is over, so now I'm ready to go and it should be fun."

PHILADELPHIA -- After a full training camp and a few preseason games, Vincent Lecavalier has grown familiar with his new orange jersey.

However, he said it will be a different feeling when he skates onto the ice here at Wells Fargo Center for his first regular season game as a member of the Philadelphia Flyers.

"I'm definitely really excited," Lecavalier said. "Any opening night, especially when it's your first game with a new team, it's definitely extra special. I've never been through it. I've had a lot of great years in Tampa but I'm happy to be here. I think we have a great hockey team and I'm just excited to start."

Lecavalier, who will start centering the second line between Wayne Simmonds and Brayden Schenn, said he hasn't needed to change much of his game to adjust to new teammates and a new style of play.