Wilcox has served as Johnson's backup for the past four games after appearing in 28 games for the Rochester Americans this season. He previously played 13 games for Florida's AHL affiliate in Springfield.
"There would be a lot of things that go into play," Housley said. "How Philly does, obviously. If they win the game, there could be some decisions at that point. And then how this game goes forward here. Hopefully we don't have to make a change but obviously there's something to think about."
Johnson allowed six goals on 33 shots in a loss to Tampa Bay on Friday, but Housley said the goaltender earned one last start with his overall body of work this season.
"I think Chad has given us some really good hockey games," he said. "Obviously, the last couple he's been a little off, but I think he needs to get back in net. He's proven that he's had some really good games. We'll see where the game brings us."
Josh Gorges will step into the lineup on defense in place of Justin Falk. The rest of the lineup will remain the same from the game in Tampa.
The Sabres erased three deficits in that game against the Lightning, which saw forwards Casey Mittelstadt and Alex Nylander both score their first NHL goals. They lost the game on pair of quick third-period goals, which Housley attributed to missed defensive coverage.
"I think it's a challenge for us going into this game because I thought we played a heck of a game in Tampa and it just goes back to details and playing in our own end and having the respect back there," he said.
"We totally got away from that [in the third period]. You look at the goals, they're just coverage and picking up and trying to cheat to offense. And that's what happens against good teams."
Coverage on MSG-B begins at 6:30 p.m., or you can listen live on WGR 550. Puck drop is scheduled for 7.