Keefe has been the head coach of the AHL's Toronto Marlies for the last five seasons.
The Leafs had lost six games in a row before making the change, falling to 9-10-4.
Since Keefe took over, Toronto has won two straight, both on the road, 3-1 at Arizona and 5-3 at Colorado.
"It's two games, so it's hard to do a whole bunch different," Wings coach Jeff Blashill said. "I would say for sure in their D zone coverage, a difference in where their wings stand. They protect the middle, where Babs would have them cut off the top. That's just a difference in philosophy. Some teams do either one.
"No. 2, in the O-zone it looks more of a five-man unit with a de-active D, where Babs' teams got the puck to the top and shot it with chaos at the net, as a result were one of the hardest teams to play against that way. This presents different challenges. Other than that, I haven't seen a whole bunch of differences. Obviously, (Tyson) Barrie is on the one power-play unit and (Mitch) Marner is not in the lineup, so that'll be a decision at that time. This will be different. They've had a few practices, so we'll see."