Anaheim came out flying at the start and rode that wave to their first win of the series.
"I felt like the first couple of shifts were good then we got back on our heels," said Oilers head coach Craig MacTavish after the game.
In a somewhat surprising move, Anaheim head coach Randy Carlyle elected to start Jean-Sebastien Giguere for the game.
Edmonton had the territorial advantage early but Anaheim registered the game's first scoring chance. Samuel Pahlsson took advantage of a giveaway in the slot and wristed the puck quickly on Roloson.
Anaheim started to carry the play in the first period from the three-minute mark on. Andy McDonald broke in on the right side and tried to backhand a shot five-hole on Roloson. A minute later, the Oilers found themselves in trouble but Anaheim was unable to score on a scramble in front.
Eight minutes into the period, Anaheim scored to take their first lead of the series. Dustin Penner tried to throw the puck in front and it went off the skate of Jaroslav Spacek and into the net.
The Oilers ran into some penalty trouble midway through the period when successive penalties to Moreau and Smyth put them down two men. Roloson made a big stop on Andy McDonald early in the two-man advantage as Anaheim moved the puck around well. Despite the sustained pressure, Edmonton's PK unit was able to kill off the penalties.
Shots on goal 12 minutes into the opening period were 12-1 for Anaheim.
Anaheim continued on the attack and eventually scored again to move ahead 2-0. Dustin Penner took the puck off the end boards and skated in front where he beat Roloson on a low wrister.
"They haven't gotten any breaks to this point in the series," said MacTavish. "They got a break on the first one, the second one found its way through."
Penalty trouble got the Oilers behind the eight ball late in the first. A bench minor for having too many men followed by delay of game to Jason Smith.
On the ensuing five on three, Jarret Stoll held up his opponent and on the delayed penalty Ryan Getzlaf ripped a shot by Roloson to give the Ducks a three-goal lead.
Shots on goal after one were a record-breaking 25-3 in favour of Anaheim.
Just as the Stoll penalty was expiring early in period two, Pisani created a turnover in the neutral zone and broke in alone on Giguere. Before he could get a shot away, he was upended by Beauchemin giving Edmonton its first power play.
42 seconds later, Samuel Pahlsson was sent off for hooking to give the Oilers a two-man advantage. The penalty parade continued with a penalty to Hemsky followed 20 seconds later by a penalty to Anaheim's Ryan Getzlaf.
On the four-on-three power play, the Oilers scored to draw the game to 3-1. Pronger found Marc-Andre Bergeron at the point where he wired it top corner.
The penalties kept coming on both sides and eventually Anaheim scored on a four-on-four situation to regain their three-goal edge. Ruslan Salei's blast from the right point found its way inside the right post behind Roloson.
Seven minutes into the period, a crushing check by Pronger on Selanne helped set up Edmonton's second goal. Horcoff picked up the puck at the point where he rifled it on net. Smyth tipped it in front past a screened Giguere.
Minutes later, Pronger threw the puck on net and Georges Laraque was right there to put home the rebound and make it a one-goal game.
After the Laraque goal, the Oilers continued to press for the equalizer. Torres and Dvorak both had great chances in the slot to tie it up but Giguere was solid in the Anaheim goal.
The momentum stalled somewhat after successive penalties to Staios and Smyth put the Oilers down two men. Edmonton was able to kill off Anaheim's seventh and eighth power plays.
Late in the second, Todd Marchant won a draw back to Joffrey Lupul who wired it glove side past Roloson to put Anaheim ahead by two goals once again.
Shots in the second were 13-10 Edmonton, giving Anaheim a 35-16 shot advantage through 40 minutes.
Midway through the third, Getzlaf was sent off for tripping Moreau in the neutral zone, giving Edmonton a chance to make it a one-goal game. 47 seconds later, Hemsky was tripped in front of the Anaheim net by Scott Niedermayer to put Edmonton up two men.
Anaheim did a great job killing off the penalties and just as Niedermayer came out of the box, he broke in alone on Roloson. The Oilers goaltender made a huge stop on Niedermayer to keep his team in the game.
With time winding down, Joffrey Lupul added an empty-net goal to clinch the outcome for Anaheim. NOTES: Raffi Torres and Radek Dvorak returned to the lineup for Edmonton, scratching Toby Petersen and Todd Harvey... Travis Moen drew into the lineup for Anaheim with Todd Fedoruk a healthy scratch... Anaheim's 25 shots in the first period was the most allowed in one period by the Oilers in franchise playoff history. The old record was 20 shots set by the Vancouver Canucks in the first period on May 8, 1992. Edmonton won that game 3-2.