Sestito was ejected from the game for an illegal check from behind and was suspended for four games by the NHL Department of Player Safety on Thursday.
"Any time you lose a guy on your blue line, it's difficult to replace because you only have six of them," Jets forward Blake Wheeler said. "He's one guy who does a great job at breaking the puck out. He's a nightmare for forecheckers. He can just seem to slide by guys and move the puck into those big holes.
"He's going to be missed. He's a heck of a player for us."
Enstrom isn't the first Jets defenseman who has gotten injured this season. Tyler Myers has missed 57 games with two separate lower-body injuries, Ben Chiarot missed 12 games with an upper-body injury, Mark Stuart missed 11 games with a lower-body injury and Enstrom missed five games previously with a lower-body injury.
"He's huge," defenseman Jacob Trouba said of Enstrom. "He's been one of our best defensemen all year long and he'll definitely be missed."
Enstrom has 14 points (one goal, 13 assists) in 60 games and is averaging 21:54 of ice time per game.
