The center has three goals and three assists in his past two games for the Maple Leafs, who have won six of their past seven (6-1-0) and seven of their past nine (7-1-1). Matthews, the No. 1 pick in the 2016 NHL Draft who grew up in suburban Scottsdale, Arizona, has 101 goals in 187 NHL games.
Toronto is 3-1-0 on its six-game road trip and is in second place in the Atlantic Division.
The Coyotes have lost six of eight (2-5-1), allowing at least four goals in four of their past six games, and are 10-14-3 at Gila River Arena. They have an NHL-low 23 points on home ice. Arizona is five points behind the Minnesota Wild for the second wild card into the Stanley Cup Playoffs from the Western Conference.