Martin Hanzal scored for Arizona (34-36-7), which was eliminated from playoff contention with the loss.
"Well, it's mathematically [official that we're eliminated], but it's something that's been hovering around us for a while, so it's not as if it's a shock," Coyotes coach Dave Tippett said. "It's unfortunate. We came into this season with our goal of making the playoffs. We knew we were going to be a very young team, and it was going to be an uphill battle, but we said at the start of the year this team has to grow this year. From where we were last year, we've got growth started, so we're moving in the right direction."
The Coyotes played without defenseman Oliver Ekman-Larsson, who did not take warmups and was a late scratch due to illness.
Hanzal gave Arizona an early lead when he scored on a tap-in from the slot with 2:53 remaining in the first period. He sustained an upper-body injury later in the period and did not return.
"I think [Hanzal] is such a big part of our team, and you see how good he is defensively and offensively. When a guy goes down like that, it's going to hurt your team," Coyotes forward Max Domi said. "[Kyle Chipchura] came and played with [me and Anthony Duclair] and he was great. We just couldn't get the puck to him enough, and that happens, but you don't like seeing your guys go down like that."