But it certainly wasn't for a lack of effort - or chances.
The Flames continued to create opportunities, they just couldn't finish enough of them, as has been the case in recent outings.
In the end, they outshot the Avs 33-26.
Coming into the tilt, they had been shut out in back-to-back games: 3-0 to the Coyotes on Saturday and 6-0 to the Golden Knights on Sunday.
In the loss to Arizona, they outshot the homeside 37-24 and against Vegas, they fired 34 pucks on net.
Derek Ryan broke the lengthy goal drought in the second period with a great play born from the hard work of linemate Milan Lucic.
It took 92 shots to finally find paydirt during the drought.
Along with Dillon Dube, they were the standout trio for Calgary in the defeat, battling hard and making things happen in the offensive zone all night.
Andrew Mangiapane had the other Calgary tally while workhorse David Rittich made 23 saves.
Calgary-kid Cale Makar started the play that led to Colorado's first goal of the game 3:21 in, getting to a loose puck in the high slot in Colorado's zone just before Elias Lindholm.
One of the early favourites for the Calder Trophy as rookie of the year, the young blueliner picked up the puck and hit the jets, getting it quickly ahead to Nathan MacKinnon, who slid a backhand pass to Andre Burakovsky who snapped it home shortside past Rittich with very little room to work with.
It was Colorado's first shot of the night.
It was Makar's 18th dime of the season. He came into the tilt second in Avs team scoring with 22 points (seven behind MacKinnon), most recently chipping in four assists in Colorado's 5-4 overtime win against the Canucks in Vancouver on Saturday.
Philipp Grubauer made a glove save on a solid chance from Matthew Tkachuk just past the three-quarter pole of the frame, Mangiapane pulled down on the play by J.T. Compher who was sent off for interference.
On the ensuing powerplay, the Flames threw everything but the kitchen sink at the Colorado net, Grubauer stopping two doorstep tip attempts by Tkachuk, then getting across to rob Ryan who took a pass from Mikael Backlund as he split the D, going forehand-backhand-forehand but denied.
The Flames led 12-3 in shots with just over two minutes left.
But Burakovsky scored his second on Colorado's sixth shot of the frame with 1:35 left in the first, wiring one from out near the edge of the left faceoff circle on another tough angle at the other side of the cage, again putting it shortside.
The Avalanche came out in the second and applied some pressure, peppering Rittich on a powerplay with Mark Giordano in the bin for tripping MacKinnon.
The best chances came courtesy of Valeri Nichushkin, who took a pass to Rittich's left and spun out front gettting a pair of shots off, then former Leaf Nazim Kadri getting another whack at the rebound, the Calgary 'tender on his butt and able to squeeze his legs closed and finally trap it.
Colorado led 15-14 in shots after the advantage.
Vladislav Kamenev finished off a quick three-way passing play at the 13:15 mark to make it 3-0, keeping his stick on the ice to redirect a cross-ice pass from Compher, with Nichushkin getting the other helper.
Then came the Ryan tally.
About a minute before the goal, Milan Lucic tipped a Giordano point shot and then got four more whacks at it as Grubauer kept snapping his left pad out as the two circled towards the far post.
Lucic kept up the hard work on the shift, winning a battle on the boards for the puck and feeding it out to Ryan, who turned and took a few strides before snapping a perfectly-place laser far-side over Grubauer's left shoulder.