Defenseman Kris Letang will be a game-time decision for the Penguins, who are third in the division, three points behind the New York Islanders and Washington Capitals and three ahead of the Hurricanes. Letang has missed 11 games with an upper-body injury.
The Hurricanes hold the first wild card from the Eastern Conference, one point ahead of the Columbus Blue Jackets and four ahead of the Montreal Canadiens.
Goalie Matt Murray will start for the Penguins, who are 6-2-1 in their past nine games.
The Hurricanes are 11-3-1 in their past 15 games.