The Lightning, who are 12-1-2 in their past 15 games and have the best record in the League, will try to reach 50 wins in their 66th game, which would equal the Detroit Red Wings in 1995-96.
Ottawa will be playing its first game under interim head coach Marc Crawford, who replaced the fired Guy Boucher on Friday. Crawford has a 549-421-78 record with 103 ties in 15 seasons with the Quebec Nordiques, Colorado Avalanche, Vancouver Canucks, Los Angeles Kings and Dallas Stars. He won the Stanley Cup in 1996 with the Avalanche.
The Senators are on a six-game losing streak and are 3-13-0 in their past 16 games.