Defenseman Jon Merrill and forwards Adam Erne, Robby Fabbri and Sam Gagner could each be in the lineup against the Tampa Bay Lightning at Amalie Arena on Wednesday (5:30 p.m. ET; NBCSN, SN1, SUN, FS-D).
The four, along with forward Filip Zadina, have been in NHL COVID-19 protocol.
Coach Jeff Blashill said Erne and Fabbri would play Wednesday and the Red Wings would decide on Gagner and Merrill prior to the game. Zadina is likely to return against the Lightning on Friday.
Erne and Fabbri have each missed eight games; Gagner, Merrill and Zadina have missed six.
Fabbri began the season at center but will play on the left wing with center Dylan Larkin, partly to ease in and partly because forward Tyler Bertuzzi likely will miss the next four games and possibly the next six with an upper-body injury, Blashill said.
"We have to make sure we temper our expectations of the guys coming back, and we can't ask them to shoulder too much of the load because of the fact they've been off for a while," Blashill said.
Fabbri said he tested positive twice Jan. 18 and isolated himself in his bedroom. He experienced symptoms from the second day through the fifth, before he began to recover.
"We knew this was the risk coming into the season," Fabbri said. "It's something that everyone's going through, not just professional athletes. It was no joke there for a couple days." -- Nicholas J. Cotsonika