The center played 18:43 and had seven shots on goal.
"I felt fine," Matthews said. "I think a little bit rusty, but I think after the first period I felt like I had my legs under me. All in all, it was a great win by the boys, an all-around team effort."
Toronto goalie Frederik Andersen made 26 saves in his first start since Feb. 20; he missed four games with a lower-body injury.
"I felt pretty good," Andersen said. "I think working hard to get back, and obviously in the last few days felt like I was inching closer to [getting] back. Felt pretty good right away, and the guys did a good job of just keeping them to the outside in the first period, especially, and taking it to them a little bit more. That was helpful."
Matthews has played with the injury for much of the season and said he aggravated it in a 2-1 overtime win against the Calgary Flames on Feb. 24. He missed two games against the Oilers, a 4-0 win Saturday and a 3-0 win Tuesday. Matthews played with usual linemates Mitchell Marner and Joe Thornton.
"I thought Auston skated well, I thought he looked good on the power play," Toronto coach Sheldon Keefe said. "Their line didn't get a whole lot going at 5-on-5 other than a couple sequences, but a good night for them. It's a tough kind of [night] because once we get a lead like we did, that line really loses its rhythm. I stopped playing them as much as I normally would. I don't play them in the same type of spots I normally would. This is a tough night for players like that on our top line. I disrupt their rhythm quite a bit at even strength."
Andersen was the only Maple Leafs goalie to allow a goal to the Oilers during the three-game sweep, to Ryan Nugent-Hopkins at 13:46 of the second period. Jack Campbell won on Saturday and Michael Hutchinson won on Monday.
"Fred, I thought, was really good," Keefe said. "Looked strong, moved well, looked confident in the net. When we had breakdowns and we were on our heels a little bit at different times through second, third and at the start of the game, he was really good for us. That's obviously a very good sign."
The Maple Leafs play at the Vancouver Canucks on Thursday, then at Vancouver on Saturday.
NHL.com staff writer Mike Zeisberger and independent correspondent Derek Van Diest contributed to this report
