Henrique, who is a finalist for the Calder Trophy as the NHL's top rookie, spent much of the regular season between captain Zach Parise and Ilya Kovalchuk.
In Game 4 of the Eastern Conference Finals against the New York Rangers on Monday at Prudential Center, he'll work with Patrik Elias and Kovalchuk.
"Nothing changes in my game or their game," a confident Henrique told NHL.com. "We're not drawing up a whole new system for this game because we didn't win [Game 3]. We're getting our chances and just have to execute … you have to score goals to win games, and hopefully we will. All the guys like the combinations, so hopefully it gives us a spark."
Henrique, 22, was centering the team's third line with Alexei Ponikarovsky and David Clarkson. The change comes at a time when DeBoer has decided to give Jacob Josefson an opportunity to make his playoff debut with Henrique's former linemates.
For DeBoer, moving Henrique around isn't much of a concern. He has two goals, eight points and a plus-7 rating in 15 playoff games for the Devils.
"I think you forget how young he is, at least I do," DeBoer said. "I think it comes down to hockey sense, and responsibility … he's a responsible player. He's won before, which I think has put him in situations where he's had to play on the right side of the puck and put the puck in the right place and do the right thing. I think that those experiences have really quickened the learning curve at this level for me to be able to put him out there. I don't even think about his age now; we're way beyond that. He just gets the job done."
Follow Mike Morreale on Twitter at: @mike_morreale