Curtis McElhinney made 25 saves, 22 in the last two periods, for the Maple Leafs, who are four points ahead of the Tampa Bay Lightning for the second wild card into the Stanley Cup Playoffs from the Eastern Conference.
"You're kind of waiting for them to make a little bit of a push," McElhinney said of the Panthers. "With them playing the night before, I think they were a little slow to get started but they certainly poured it on.
"It's just one of those things; you've got to do your job to make sure you're in the game when those shots come. It feels tremendous; I'll never complain about playing that's for sure."
WATCH: All Panthers vs. Maple Leafs highlights
McElhinney played with goalie Frederik Andersen (upper body) unavailable.
Auston Matthews scored his 35th goal of the season to break Wendel Clark's record for goals by a Maple Leafs rookie set in 1985-86.
"Just to be in the same sentence as a guy like Wendel Clark is obviously a big honor," Matthews said. "A lot of credit goes to my linemates all season, it's definitely pretty special."
Florida (33-32-11), which lost at the Buffalo Sabres 4-2 on Monday, is nine points behind Boston for the second Eastern wild card with six games remaining.