Denis Malgin scored, and James Reimer made 21 saves for the Panthers (11-13-6), who have lost four in a row (0-3-1).
"I feel that we come into the game with great intentions to [play with pride and passion] and we just let it slip away," Florida defenseman Aaron Ekblad said. "We're a few mistakes here and there from being right in this game until the very end so I don't know what needs to change, but we'll figure it out at some point. We need to."
Malgin scored on a rebound at 2:20 of the first period to give the Panthers a 1-0 lead.
Niederreiter tied it 1-1 with a one-timer at 15:22, extending his goal streak to three games.
"I think for me, personally, probably confidence is obviously a big thing," Niederreiter said. "Staying on [the right wing] for quite some time for now, that's definitely helped my game a lot."
Niederreiter gave the Wild a 2-1 lead at 11:54 of the second period.
Eric Staal made it 3-1, scoring off a backhand pass from Mikael Granlund at 15:29. It was Granlund's 300th NHL point.
Parise pushed the lead to 4-1 at 1:02 of the third period, and Jonas Brodin made it 5-1 at 3:51.
"We're having fun," Parise said. "They're buzzing, we're moving our feet, we're talking all the time and we're getting the results right now."