The San Jose Sharks forward was disciplined for cross-checking Vegas Golden Knights forward Pierre-Edouard Bellemare in Game 1 of the Western Conference Second Round on Thursday.
Kane will not be eligible for Game 2 of the best-of-7 series at Vegas on Saturday (8 p.m. ET; NBC, CBC, SN, TVAS). The Golden Knights won Game 1 7-0.
"It's difficult but it's not," San Jose coach Peter DeBoer said before the ruling. "It's like an injury. If he's out, the next man up. We'll stick somebody else in there. It doesn't change our preparation."
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The incident occurred 3:25 into the third period. Kane was assessed a major penalty for cross-checking and given a game misconduct. Bellemare left the game but returned with 10:59 remaining.
Kane is participating in the Stanley Cup Playoffs for the first time. He has scored three goals, tied with Tomas Hertl and Marcus Sorensen for the Sharks lead.
Since being acquired in a trade with the Buffalo Sabres on Feb. 26, Kane has played left wing on the top line with center Joe Pavelski and right wing Joonas Donskoi. Kane had 14 points (nine goals, five assists) in 17 games with the Sharks.
Joe Thornton practiced at center on a line with Kane and Pavelski on Friday, with Donskoi sitting out, but will not play in Game 2. Thornton has not played since Jan. 23 because of a knee injury and said he remains day to day.
"Joe is coming along well," DeBoer said. "Every day he's getting a little bit better. He's looking a little bit better on the ice. He's not going to play next game."
An option could be moving Hertl from second-line left wing. He scored 22 goals during the regular season, tied with Pavelski for second on the Sharks to Logan Couture's 34. Sorensen could get moved up from the fourth line if the line of Hertl, Couture and right wing Mikkel Boedker remains together.
