Joonas Korpisalo allowed five goals on 29 shots in his first start of the season.
"That's the learning curve for us," Columbus captain Nick Foligno said. "We're a young team. That's not an excuse. We expect to be better, but that's the battle we're going to fight this year, is thinking we're a good hockey team [and] knowing we're a good hockey team. That team, they've done it a lot longer than we have, but we're a good hockey team, and we have to start thinking like that and knowing that every time we step on the ice, we have to instill [it] our game a little more."
Kane made it 1-0 1:33 into the game with a rising wrist shot from the right face-off circle. Saad, who had a hat trick against Pittsburgh, scored a power-play goal to make it 2-0 at 6:04 of the first period.
Toews made it 3-0 at 10:14 of the second with his first goal of the season, assisted by Saad. Milano scored 31 seconds later to make it 3-1.
Kane set up Jan Rutta's first NHL goal at 12:51 with a backhand pass to make it 4-1.
Richard Panik scored at 14:05 of the third period to make it 5-1.