Jones is 6-4-2 with a 1.98 goals-against average and .938 save percentage since Jan. 31, and will make his 45th start this season for San Jose, which is 1-2-1 in its past four games after going 5-1-0 in its previous six games.
The Sharks are in second place in the Pacific Division, 10 points behind the Vegas Golden Knights and two points ahead of the Los Angeles Kings.
Forward Matthew Highmore will make his NHL debut and goaltender J-F Berube will start for the Blackhawks, 3-2-0 in their past five games following an eight-game losing streak (0-7-1).
Highmore, 22, was recalled from Rockford of the American Hockey League on Monday; he has 35 points (21 goals, 14 assists) in 56 AHL games this season.
Chicago trails the Anaheim Ducks by 12 points for the second wild card into the Stanley Cup Playoffs from the Western Conference.