McDonagh played the first period, skating 7:53, putting one shot on net and taking a tripping penalty late in the period but did not come out of the locker room for the second.
The nature or extend of the injury is not immediately known. The team didn't specify if it was an upper-body or lower-body injury.
McDonagh is one of the Lightning's leaders on the blue line. He ranks second on the Bolts for average time on ice (21:13) and paces the team for average shorthanded time on ice (3:30), ranking fifth overall in the NHL.
McDonagh also leads the Lightning for blocked shots (80).
McDonagh has scored a goal and provided 10 assists in 40 games this season. The 30-year-old blueliner is two points away from reaching 300 career points in the League.
