A Mason Appleton tripping penalty 6:05 into the second put Pittsburgh on the man advantage. Despite a couple early stops from Brossoit, he couldn't get his left leg on Jake Guentzel's third of the season, a tap-in after a deflected pass from Brian Dumoulin.
Just 41 seconds later, Sam Lafferty jumped on a puck that bounced off the end boards and squeezed it between the post and Brossoit's left skate as the Jets goaltender was coming across to increase Pittsburgh's lead to 3-1.
The Jets responded at the halfway mark of the second period. From the left circle, Patrik Laine sent a feed to Scheifele in the middle of the ice. His initial redirect went off Kris Letang's stick and right back to him - and the Jets centre sent a backhand over a sprawling Jarry to pull the Jets back within one.
It was the second straight game the Jets had cashed in on the power play, but later in the period, the Jets gave up a shorthanded goal for the second consecutive night.
"We had some looks on the power play. You never want to give up shorthanded goals on the flip side of things," said Morrissey. "Those are backbreakers. We have to clean that up. The number one thing when you're out there on the power play, regardless of if you have an extra guy, you have to out compete the other team and not give anything up."
After Dominik Simon restored Pittsburgh's two-goal lead late in the second, Maurice shuffled the lines for the third period, and while it resulted in some chances - including Wheeler hitting the post off the rush - the Penguins would strike again. Lafferty's second of the game, a wrist shot that banked off the skate of defenceman Anthony Bitetto and by Brossoit to make it 5-2 Penguins.
Guentzel and Aston-Reese added their second goals of the game late in the third to round out the scoring.
"We had a tough night tonight," said Maurice. "We've been a pretty damn good team. We weren't tonight. I'm leaving it."