Odjick's final season playing in the NHL came with Montreal in 2001-02. During the preseason before the 2002-03 season, he suffered a concussion. A puck struck him in the back of the head in practice. Odjick spent the first four-plus months of the season on the injured reserve list. When he was cleared to play, the Canadiens assigned him to play for their American Hockey League affiliate. Odjick refused the assignment and was suspended by the Habs on February 22. Thereafter, he retired.
For his NHL career, Odjick appeared in 605 regular season games (64 goals, 73 assists, 137 points, 2,567 penalty minutes) and 44 games in the Stanley Cup playoffs (four goals, one assist, five points, 142 penalty minutes). Through the NHL's 2015-16 season, Odjick ranked 17th on the league's all-time penalty minute list.
After his NHL career ended, Odjick resettled permanently in Vancouver. The former NHL tough guy played men's senior AAA league hockey in 2004-05 for the Horse Lake Thunder, where his teammates included fellow former NHL players Theoren Fleury, Sasha Lakovic and Dody Wood. Proud of his First Nation heritage, Odjick partnered with the Musqueam First Nation in British Columbia to manage the Musqueam Golf and Learning Academy. Odjick also acted in a supporting role as a character with the name "Gino" in "Ronny Nomad the Legendary Napkins of Wood," a 12-minute Canadian short film.
Odjick publicly announced on June 26, 2014 that he had been diagnosed with a rare and terminal endocrine disease called AL amyloidosis, in which the sufferer's antibody-producing cells cease to function properly.