It was the first visit to Anaheim since Game 2 of last year's First Round, in which the Sharks eliminated Anaheim in a sweep that left a bad taste over a long Ducks summer.
The Sharks downed the Ducks 4-1 two nights ago at SAP Center in the preseason opener for both teams.
Tonight the Ducks got on the board five minutes into the game on a tap-in by Ondrej Kase off a nice Adam Henrique feed, the first of two goals on the night for Kase.
San Jose got even soon afterward when a Joakim Ryan slap shot was deflected by Antti Suomela past goalie Ryan Miller.
The Ducks made a change midway through the second, with Jared Coreau taking Miller's spot in the crease.
Jakob Silfverberg put the Ducks back on top with three minutes left in the period with a snipe from the top of the right wing circle.
The Sharks knotted it up again a little less than five minutes into the middle session when Kevin Labanc filled an open net on the rush off a Joonas Donskoi pass.
Kase's second goal of the game gave the Ducks a 3-2 lead six minutes into the second period, a beautiful snipe from the slot on the rush.
San Jose tied it with a fluky goal later in the period, as an attempt by Radim Simek to send the puck into the crease nicked off goalie Miller's stick and got under him.
The Sharks took their first lead soon afterward on a point shot through traffic by defenseman Jacob Middleton, and they made it a two-goal cushion with 8 1/2 minutes left courtesy of a Lukas Radil one-timer from the slot.
San Jose put it away with 3:33 left on a tap-in by Donskoi, his second of the night, and the second of the evening by Suomela thirty seconds later.
The Ducks travel to Arizona to take on the Coyotes on Saturday.
