Goalie Mike Smith suffered a lower-body injury during the third period of Tuesday's game at the Ottawa Senators, left the game and did not return.
Arizona was trailing, 3-2, when Smith left the game and lost 7-4.
Speaking to reporters immediately after the game, Head Coach Dave Tippett said it was too soon to offer detailed information on the extent of Smith's injury. He said the team would know more on Wednesday.
"We'll make sure we do our due diligence, find out what it is and we'll probably have more (information) tomorrow," Tippett said.
Smith fell to the ice in pain after getting twisted in the crease while lunging to make a save. He was helped off the ice and replaced by backup Louis Domingue at 7:18 of the third period.
Smith stopped 27 of 30 shots before suffering the injury. Domingue stopped 8 of 11 shots in relief.
• Rookie Dylan Strome made his NHL debut on Tuesday and assisted on Arizona's first goal, scored by Tobias Rieder at 12:18 of the first period. It was Strome's first NHL point.
Strome's parents were among the spectators to witness his debut at the Canadian Tire Centre. His billet parents also attended the game. Strome grew up in Mississauga, Ontario, which is about 300 miles from Ottawa.
Strome played 16:28 and won two of three face-offs.
• Jordan Martinook scored Arizona's final two goals, 8:36 apart in the third period. It was the first multi-goal game of Martinook's career. He scored nine goals last season as a rookie.
"They locked the neutral zone up pretty good and we just weren't smart enough tonight to figure out how to get by it," Martinook said. "The game plan should be simple if they're locking the neutral zone up; just get it by them and go in on the forecheck, but for some reason tonight we weren't doing that and turning the puck over, and whenever you turn the puck over against any team in this league it's not going to be good."
Video: Jordan Martinook discusses Coyotes' 7-4 loss at Sens
Tippett liked Martinook's effort in the ugly loss.
"He gives you everything he's got," Tippett said. "He's one of the guys in the trenches working as hard as he can work. There's some guys that can take some lessons from that."
• Captain Shane Doan assisted on Oliver Ekman-Larsson's power-play goal at 1:01 of the third period. It was Doan's 550th assist, which ties Dale Hawerchuk for second place on the franchise's all-time assists list. Thomas Steen holds the record with 553.
"We knew they were going to come out with a little bit of jump after (playing) last night." Doan said. "They did and we didn't match it and that's unfortunate. We have to be better than that."
Video: Shane Doan discusses Coyotes' 7-4 loss at Ottawa
• Defenseman Kevin Connauton made his season debut after starting the campaign on the injured reserve list. Connauton played 10:34 and took one shot on goal.
• Center Martin Hanzal played 22:40, took three shots on goal, delivered five hits and won 21 of 31 face-offs.
Video: ARI Recap: Defense falters in 7-4 loss to Sens