Mike Smith will start in goal for the Coyotes, who posted a 5-1-2 record in the preseason but haven't played a game in eight days.
Besides the prospects, several other newcomers will play their first game with Arizona including defensemen Alex Goligoski and Luke Schenn, and forwards Radim Vrbata and Ryan White. Vrbata is starting his third stint with the Coyotes.
On the flip side, forward Jamie McGinn likely won't make his debut due to an upper-body injury he suffered in training camp, and prospect Dylan Strome, the third overall pick in the 2015 NHL Draft, is expected to be a healthy scratch.
"We've got a lot of young guys here we're going to have to integrate," Tippett said. "You can't just throw them all out there to the wolves. We're going to make sure everybody can do their best to play their best. (Strome) will get opportunity. He has to be able to get in there and play his game. When he has the puck he's a good player; he makes good plays but positionally and strength with the puck and playing without the puck are all things that, not just Dylan but all young players have to learn."
Doan will enter the game needing just four goals to reach 400 for his NHL career, which began in 1995-96, and 55 points to reach 1,000.
