The Penguins would pull one back before the end of the frame as Evgeni Malkin turned the corner behind Crawford's goal and slide a pass into the slot for Jake Guentzel to put home on the far side at 16:04.
Pittsburgh tied the game at 10:57 of the third as John Marino fed Bryan Rust with a cross-ice feed that the forward beat Crawford on with a one-timer to push his point streak to six straight games.
For the sixth time this season, Chiacgo went to the extra frame, where they dominated chances but couldn't find the winner as the game went to a shootout. The Penguins took the skill competition two goals to one as the Blackhawks fell 3-2.