The Blues are one of three teams chasing the Avs and are trying to get back into the playoff picture, as they are three points out of eighth place in the west.
"We know they are a pretty good team," said Avalanche defenseman Samuel Girard. "They're only three points behind us. That is why the game tonight will be huge for us and for them. We're going to have to be ready for the game tonight."
Colorado hasn't had much success recently versus St. Louis, with the Blues winning four straight and having earned points in each of the last 12 matchups with the Avs (9-0-3). St. Louis is 13-2-0 in its last 15 games versus Colorado at Scottrade Center.
Avalanche head coach Jared Bednar sees a lot of parallels between this evening's contest versus the Blues and the team's meeting at the Minnesota Wild on Tuesday, a game the club won 5-1 to push its point streak to eight games (5-0-3).
The Avs went 3-0-1 versus the Wild this year, winning the season series for the first time since 2013-14.
"This is another tough test. This is a lot like going into Minny, you know," Bednar said. "Tough building to come in and win in and a team that we haven't had a lot of success against. It's another challenge for our team and hopefully we're ready to accept that challenge and continue to do the things that made us successful in Minny."
Bednar noted that the past doesn't matter for the Avs' matchup tonight with only 13 games remaining in the regular season and seeding in Western Conference still very much influx. Finding a way to continue to climb in the standings is Colorado's motivation.
"I'm not worried about the last seven, five, 10 games we've played against these guys," Bednar said. "We have to narrow our focus to tonight's game. Shift-by-shift, period-by-period, we got to go out and play the right way. We have to be committed to playing the right way, to taking care of the puck and making sure that we put enough pressure on these guys.
"We're not going to try and redeem ourselves for our record against these guys for the last year or two years. We're looking to get the two points, because that's the most important thing for our team."
The Avs and Blues will meet for the fifth and final time this year on April 7 in Colorado in what will be both clubs' last contest of the regular season.