MacKinnon, who has 61 points (24 goals, 37 assists) in 49 games, has missed the past eight games because of an upper-body injury.
The Avalanche will try to set a franchise record with their 11th consecutive home win; they have outscored opponents 38-14 during their 10-game streak. They last lost at home 3-1 to the Arizona Coyotes on Dec. 27. The Quebec Nordiques won 10 straight at home twice, from March 6-April 16, 1995, and from Nov. 26, 1983-Jan. 10, 1984.
Colorado is three points behind the Minnesota Wild for the second wild card into the Stanley Cup Playoffs from the Western Conference.
The Oilers will look to end a six-game losing streak (0-6-0); they lost 1-0 at the Coyotes on Saturday and have been outscored 26-14 in the streak. Edmonton has lost the first two games of a three-game road trip and is 6-13-2 in its past 21.