Hischier will miss his third straight game with an upper-body injury. Vatanen left in the second period of a 3-0 win at the Philadelphia Flyers on Thursday with an undisclosed injury and has been placed on injured reserve.
Goalie Keith Kinkaid is expected to make his third straight start for the Devils, who look for their third consecutive win after going 1-6-0 on a seven-game road trip.
Goalie Jonathan Bernier will start for the Red Wings, who will try to win for the fifth time in six games.
Inclement weather along the East Coast on Thursday forced Detroit to travel Friday; the Red Wings flew from Ottawa to Albany, New York, and from Albany to White Plains, New York, before busing to Newark.