Ovechkin scored his 597th goal in a 5-1 loss against the Columbus Blue Jackets on Monday. He leads the League with 39 goals and would become the 20th player to score 600.
The Capitals, 2-4-0 in their past six games, are in second place in the Metropolitan Division, one point behind the Philadelphia Flyers.
Ottawa will defenseman Erik Karlsson in the lineup after not trading before the NHL Trade Deadline, which came at 3 p.m. ET on Monday. The two-time Norris Trophy winner (2012, 2015) is two points from 500 for his career.
The Senators have lost four in a row (0-3-1) and are 17 points behind the Blue Jackets for the second wild card into the Stanley Cup Playoffs from the Eastern Conference.