Rather than sticking with the lineup that won Game 2 3-2 in triple overtime on Tuesday, he replaced center Antoine Vermette and rookie forward Teuvo Teravainen with Kris Versteeg and Joakim Nordstrom.
The moves changed Chicago's bottom two lines but failed to pay dividends in a 2-1 loss at United Center that put the Blackhawks behind 2-1 in the best-of-7 series.
Quenneville said the changes weren't related to injuries, but the length of Game 2 did play a role.
"We just wanted to get some fresh legs in there," Quenneville said. "We felt that [Versteeg] never played over a long stretch there in the last series and we wanted to get him back in there. Tough game the other day with travel and we wanted to bring some new guys in."