Franzen was put on injured reserve, general manager Ken Holland told the Red Wings website.
Franzen, who missed time last season with a concussion, skated Tuesday morning and then did not feel well; he was scratched from a 3-1 win against the Tampa Bay Lightning. He has one assist in two games this season.
"You don’t like to see anybody go through injury issues, and certainly for him he’s battled, worked hard through the summer, got himself in great position," Blashill said. "So you certainly don't want to see it, none of his teammates want to see it, I don't want to see it but it's the reality right now and I feel extraordinarily bad for him."