Rookie Dylan Larkin kept the puck on a rush that ended behind the net, spun around and fed DeKeyser for a wrist shot over Louis Domingue's shoulder with 2:52 left.
Pavel Datsyuk and Gustav Nyquist scored in the third to help the Red Wings come back from a 2-0 deficit. Petr Mrazek stopped 27 shots, and Detroit finished with five wins during a six-game trip.
Oliver Ekman-Larsson and Shane Doan scored second-period goals and Domingue made 22 saves. Arizona's four-game winning streak was snapped.
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