Scott Hartnell scored two goals for the Blue Jackets, who lost their seventh straight game.
Hartnell's goals came in the second period after Columbus fell behind 1-0 on a goal by Carolina's Jeff Skinner at 2:43. Hartnell tied the game at 1-1 at 11:15. He then he gave the Blue Jackets the lead at 18:44 when he put a rebound past Carolina goalkeeper Cam Ward, who made his fifth straight start.
Carolina's Victor Rask tied the game at 2-2 with 8:09 left in the game with a shot through traffic.
Carolina, which won its fourth straight game, outshot the Blue Jackets 35-31.
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