The Stanley Cup champions announced the honour Monday.
Blake played 14 of his 20 NHL seasons with the Kings, including six seasons as their captain. The seven-time All-Star won the franchise's first Norris Trophy in 1998 and became the club leader in games played, goals and assists by a defenceman.
The former fourth-round draft pick finished his career in San Jose in a move that irked many Kings fans. He has since returned to Los Angeles as the club's assistant general manager.
Blake will be honoured before a home game against the Anaheim Ducks. He is the sixth Kings player to have his number retired.