He replaces Brad Treliving, who became the Calgary Flames' general manager in April, and will work under Coyotes GM Don Maloney.
Regier spent 17 years as Buffalo's general manager, the longest tenure in the franchise's 44-year history. He helped lead the Sabres to the 1999 Stanley Cup final and the Eastern Conference final four times.
The 58-year-old oversaw all aspects of Buffalo's hockey operations and for the franchise's AHL affiliate, the Rochester Americans.
You don't see many. The [Drew] Doughtys, the [P.K.] Subbans, those are guys that create offense from the back and then on top of that ability, the size that he has. In the West you play against some pretty big players, and being able to clear the crease and contain the [Ryan] Getzlafs and the [Corey] Perrys and [Anze] Kopitars and players like that, we're excited about him going back there.
— Sharks general manager Doug Wilson on Brent Burns returning back to defense