The Blues need their key trade deadline pickup, goalie Ryan Miller, to play well to help keep their season alive.
Jonathan Toews' breakaway goal in overtime of Game 5 gave the Blackhawks a 3-2 series lead.
The defending Stanley Cup champions can wrap it up at home on Sunday in Chicago with Seabrook back in the lineup.
The Blues acquired Miller from Buffalo as the piece that would drive a deep playoff run.
Coach Ken Hitchcock said Miller has played "great," overall, but if the Blues are to bring the series back to St. Louis for a Game 7 Tuesday, Miller has to find a way to shut down the Blackhawks.