Pittsburgh took a 2-1 lead in the best-of-seven playoff series thanks to the goals on three consecutive shots.
Brooks Orpik added a goal in the final seconds of the second period as the Penguins stormed back from deficits of 2-0 and 3-1. Marc Andre-Fleury had 27 saves.
Boone Jenner and Jack Johnson staked the Blue Jackets to an early lead in the opening 3:18, with Cam Atkinson getting credit for a goal early in the final period that stretched the lead to 3-1.
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