Streit's backhand shot from the right circle caromed between Fleury's pads and into the net as the Flyers assured themselves of a matchup with the New York Rangers when the Stanley Cup playoffs begin next week.
Jakub Voracek scored twice for the Flyers, and Claude Giroux added his team-high 28th goal of the season. Ray Emery made 12 saves after replacing injured starter Steve Mason to start the third period.
Jussi Jokinen, James Neal and Kris Letang scored for the Penguins. Fleury stopped 17 shots and hardly looked sharp while giving up the game-winner. Pittsburgh will play either Detroit or Columbus in the opening round of the post-season.
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