Defensman Christian Ehrhoff's playing status is uncertain against Detroit on Tuesday. Ehrhoff was struck by a puck and required stitches to close a gash on his right ear.
Coach Ted Nolan provided the updates following practice Monday, a day after the three were hurt in a 5-2 loss at Philadelphia.
Lieuwen's injury means the Sabres will have to dress their seventh goalie this season.
The Sabres (21-48-9) have four games left and are guaranteed to finish in last place.